BLAD ß-Lactmase Database
A comprehensive database of widely circulated ß-Lactamases
Welcome to ß-Lactmase
Beta-lactamases are enzymes produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephamycins, and carbapenems (ertapenem) (Cephalosporins are relatively resistant to beta-lactamase). These antibiotics have a common element in their molecular structure: a four-atom ring known as a beta-lactam.
VIM beta-lactamase (Class B)
VIM (Verona integron-encoded metallo-ß-lactamase)A second growing family of carbapenemases, the VIM family, was reported from Italy in 1999 and now includes 10 members, which have a wide geographic distribution in Europe, South America, and the Far East and have been found in the United States. VIM-1 was discovered in P. aeruginosa in Italy in 1996; since then, VIM-2 - now the predominant variant was found repeatedly in Europe and the Far East; VIM-3 and VIM-4 are minor variants of VIM-2 and VIM-1, respectively. VIM enzymes occur mostly in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae.
Amino acid sequence diversity is up to 10% in the VIM family, 15% in the IMP family, and 70% between VIM and IMP. Enzymes of both the families, nevertheless, are similar. Both are integron-associated, sometimes within plasmids. Both hydrolyse all ß-lactams except monobactams, and evade all ß-lactam inhibitors.
Beta-lactam antibiotics are typically used to treat a broad spectrum of Gram-negative bacteria. Beta-lactamases produced by Gram-negative organisms are usually secreted.
Sequence presentation by:
Copyright © 2012 Dr. Asad U Khan All rights reserved
Interdisciplinary Biotechnology Unit
Aligarh Muslim University, Aligarh-202001
Uttar Pradesh, India